– Levodopa, Carbidopa used in the treatment of, among other diseases,
Parkinson's disease (PD), a condition characterized by death of dopaminergic
neurons in the substantia nigra. Increased dopamine available may increase
the effectiveness of the remaining neurons and alleviate symptoms for a time.
The pharmacologic objective is to get an exogenous dopamine-precursor known
as levodopa/L-DOPA into the dopamine-deficient brains of PD patients.
Levodopa/L-DOPA can cross the blood brain barrier, but dopamine cannot.|